2-Pyrimidinamine, 5-fluoro- (9CI)

Base Information

• Chemical Name: 2-Pyrimidinamine, 5-fluoro- (9CI)
• CAS No.: 1683-85-8
• Molecular Formula: C4H4FN3
• Molecular Weight: 113.094
• Hs Code.: 2933599590
• Mol file: 1683-85-8.mol

Synonyms:Pyrimidine,2-amino-5-fluoro- (7CI,8CI);2-Amino-5-fluoropyrimidine;5-Fluoro-2-pyrimidinamine;

Chemical Property of 2-Pyrimidinamine, 5-fluoro- (9CI)

Chemical Property:

• Melting Point: 192-193℃
• Refractive Index: 1.56
• Boiling Point: 279.7 °C at 760 mmHg
• PKA: 2.13±0.10(Predicted)
• Flash Point: 122.9 °C
• PSA: 51.80000
• Density: 1.372 g/cm³
• LogP: 0.77910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-5-fluoropyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrimidinamine, 5-fluoro- (9CI)

There total 5 articles about 2-Pyrimidinamine, 5-fluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-5-fluoropyrimidine (62802-42-0) → 2-amino-5-fluoropyrimidine (1683-85-8)

Guidance literature:

With ammonia; In methanol;

Reference yield: 53.0%

guanidine hydrochloride (50-01-1) + 1,1,5,5-tetraethyl-3-fluoro-1,5-diazapentadienium iodide → 2-amino-5-fluoropyrimidine (1683-85-8)

Guidance literature:

With sodium methylate; In methanol; acetonitrile; at 70 - 75 ℃; for 3h;

DOI:10.1016/0040-4039(95)00076-O

Reference yield:

guanidine hydrochloride (50-01-1) + 2,3,3-trifluoro-1-propenyl tosylate → 2-amino-5-fluoropyrimidine (1683-85-8)

Guidance literature:

With tetra(n-butyl)ammonium hydroxide; Yield given. Multistep reaction; 1.) methanol, RT, 0.5 h, 2.) DMSO, 70 deg C, 1 h;

DOI:10.1246/cl.1995.239

upstream raw materials:

guanidine hydrochloride

(Z)-(2,3,3-trifluoro-l-propenyl)trimethylammonium iodide

diethylamine

2-chloro-5-fluoropyrimidine

Downstream raw materials:

N-(2,4-dimethoxybenzyl)-5-fluoropyrimidin-2-amine

Refernces

• 1、 -. "Peptide deformylase inhibitors". Page/Page column. . Retrieved 2014/12/09.
• 2、 Funabiki, Kazumasa,Ohtsuki, Tetsuya,Ishihara, Takashi,Yamanaka, Hiroki. "Reactions of 1-Substituted-polyfluoro-1-propenyl p-Toluenesulfonates with Bifunctional Nitrogen Nucleophiles. A New Expedient Access to Monofluorinated Nitrogen Heterocycles". . p. 239 - 240. Retrieved 2007/10/02.