2,4-QUINOLINEDIOL

Base Information

• Chemical Name: 2,4-QUINOLINEDIOL
• CAS No.: 1677-36-7
• Molecular Formula: C9H7NO2
• Molecular Weight: 195.605
• Hs Code.: 2933499090
• Mol file: 1677-36-7.mol

Synonyms:2,4-Quinolinediol,6-chloro- (6CI);Carbostyril, 6-chloro-4-hydroxy- (7CI,8CI);6-Chloro-2,4-dihydroxyquinoline;6-Chloro-4-hydroxy-2-quinolone;6-Chloro-4-hydroxycarbostyril;

Chemical Property of 2,4-QUINOLINEDIOL

Chemical Property:

• Melting Point: >300 °C(lit.)
• Boiling Point: 303.8 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 137.5 °C
• PSA: 53.35000
• Density: 1.376 g/cm³
• LogP: 1.64600
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Aqueous Base (Slightly), DMSO (Slightly)

Purity/Quality:

98.5% ^*data from raw suppliers

4-Hydroxyquinolin-2(1H)-one AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-QUINOLINEDIOL

There total 11 articles about 2,4-QUINOLINEDIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N1,N3-bis(4-chlorophenyl)malonamide (17722-20-2) → 6-chloro-4-hydroxyquinolin-2(1H)-one (1677-36-7)

Guidance literature:

With polyphosphoric acid; at 130 - 140 ℃; for 6h;

DOI:10.1016/j.ejmech.2014.05.024

Reference yield: 94.0%

→ 6-chloro-4-hydroxyquinolin-2(1H)-one (1677-36-7)

Guidance literature:

With polyphosphoric acid; at 150 ℃; for 3h;

Reference yield: 91.3%

4-chloro-aniline (106-47-8) + diethyl malonate (105-53-3) → 6-chloro-4-hydroxyquinolin-2(1H)-one (1677-36-7)

Guidance literature:

With aluminum (III) chloride; Eaton′s reagent; at 90 ℃; for 6h; Inert atmosphere;

upstream raw materials:

malonic acid

4-chloro-aniline

methyl 2-acetamido-5-chlorobenzoate

benzylamine

Downstream raw materials:

C₁₅H₉ClN₄O₄

C₁₆H₉ClN₄O₂

6-chloro-3-(2-(4-chlorophenyl)hydrazono)quinoline-2,4(1H,3H)-dione

6-chloro-3-(2-(2-nitrophenyl)hydrazono)quinoline-2,4(1H,3H)-dione