methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

Base Information

• Chemical Name: methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate
• CAS No.: 1435482-84-0
• Molecular Formula: C₂₇H₂₀ClN₃O₃
• Molecular Weight: 469.927

Synonyms:methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

Chemical Property of methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

There total 3 articles about methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate (1435483-35-4) → methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.02,6.08,12]heptadeca-1(17),2,8,11,13,15-hexaene-6-carboxylate (1435482-84-0)

Guidance literature:

methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate; With hydroxylamine hydrochloride; sodium acetate; In ethanol; at 20 ℃; for 0.5h;

With sodium hypochlorite; triethylamine; In dichloromethane; at 20 ℃; for 14h;

DOI:10.1016/j.tet.2013.03.099

Reference yield:

5-(4-chlorophenyl)-4-iodo-1-phenyl-3(1H)-pyrazolecarbaldehyde (1002102-41-1) → methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.02,6.08,12]heptadeca-1(17),2,8,11,13,15-hexaene-6-carboxylate (1435482-84-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane / pyridine / 20 °C

1.2: 3 h / 20 °C

1.3: 1 h / 20 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.5 h / 20 °C

3.2: 14 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium acetate; sodium carbonate; In pyridine; ethanol; N,N-dimethyl-formamide; 2.1: |Suzuki Coupling;

DOI:10.1016/j.tet.2013.03.099

Reference yield:

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-57-2) → methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.02,6.08,12]heptadeca-1(17),2,8,11,13,15-hexaene-6-carboxylate (1435482-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 3 h / 90 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / ethanol / 0.5 h / 20 °C

2.2: 14 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; sodium acetate; sodium carbonate; In ethanol; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;

DOI:10.1016/j.tet.2013.03.099

upstream raw materials:

5-(4-chlorophenyl)-4-iodo-1-phenyl-3(1H)-pyrazolecarbaldehyde

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1435482-84-0 methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send