methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

Base Information

• Chemical Name: methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate
• CAS No.: 1214996-57-2
• Molecular Formula: C₂₀H₁₆ClIN₂O₂
• Molecular Weight: 478.717

Synonyms:methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

Chemical Property of methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

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Technology Process of methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

There total 1 articles about methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-54-9) → methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-57-2)

Guidance literature:

methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate; With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; water; at 20 ℃; for 0.25h;

With sodium tetrahydroborate; In tetrahydrofuran; water; at 5 - 20 ℃;

DOI:10.1002/adsc.200900438

Reference yield: 94.0%

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-57-2) → 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylic acid (1214996-60-7)

Guidance literature:

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 5h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

DOI:10.1002/adsc.200900438

Reference yield: 73.0%

methyl 2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate (1214996-57-2) + 2-formylbenzene boronic acid (40138-16-7) → methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate (1435483-35-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.tet.2013.03.099

upstream raw materials:

methyl 2-{(acetyloxy)[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylate

Downstream raw materials:

2-{[5-(4-chlorophenyl)-4-iodo-1-phenyl-1H-pyrazol-3-yl]methyl}acrylic acid

methyl 11-(4-chlorophenyl)-10-phenyl-4-oxa-3,9,10-triazatetracyclo[11.4.0.0^2,6.0^8,12]heptadeca-1⁽¹⁷⁾,2,8,11,13,15-hexaene-6-carboxylate

methyl 2-{[5-(4-chlorophenyl)-4-(2-formylphenyl)-1-phenyl-1H-pyrazol-3-yl]methyl}prop-2-enoate

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