2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

Base Information

Chemical Name:2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate
CAS No.:1255650-22-6
Molecular Formula:C₂H₄O₂*C₁₅H₁₇F₃N₂O₂
Molecular Weight:374.36
Hs Code.:

Synonyms:2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

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Chemical Property of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

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Technology Process of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

There total 5 articles about 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1255650-20-4
8-benzyl-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 1255650-22-6
2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

Guidance literature:: With hydrogen; acetic acid; 10 wt% Pd(OH)2 on carbon; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

Reference yield: 49.0%

: 1255650-20-4
8-benzyl-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

: 64-19-7,77671-22-8
acetic acid

: 1255650-22-6
2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

Guidance literature:: With hydrogen; 10 wt% Pd(OH)2 on carbon; In methanol; at 20 ℃; for 3h; under 760.051 Torr;

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 1255650-22-6
2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - -5 °C

1.2: -5 - 20 °C

2.1: dimethylaluminum chloride / n-heptane; toluene / 4 h / Inert atmosphere; Reflux

3.1: hydrogen; acetic acid / 10 wt% Pd(OH)2 on carbon / methanol / 3 h / 20 °C / 760.05 Torr

With n-butyllithium; hydrogen; dimethylaluminum chloride; acetic acid; diisopropylamine; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; hexane; n-heptane; toluene;