2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

Base Information

Chemical Name:2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide
CAS No.:1092446-07-5
Molecular Formula:C₂₃H₂₃F₃N₂O₅S
Molecular Weight:496.507
Hs Code.:

Synonyms:2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

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Chemical Property of 2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

Chemical Property:

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Technology Process of 2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

There total 9 articles about 2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 421-85-2
Trifluoromethanesulfonamide

: 1092445-35-6
2-(2-cyclobutoxy-3-methylbenzoylamino)indan-2-carboxylic acid

: 1092446-07-5
2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 192h;

Reference yield:

: 23287-26-5
3-methylsalicylic acid methyl ester

: 1092446-07-5
2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / potassium iodide / N,N-dimethyl-formamide / 96 h / 43 °C

2.1: methanol; lithium hydroxide; water / 1,4-dioxane / 18 h

2.2: pH 2

3.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

3.2: 288 h

4.1: methanol; lithium hydroxide; water / 1,4-dioxane / 20 h

4.2: pH 2

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 192 h

With methanol; dmap; lithium hydroxide; water; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 141104-65-6
ethyl 2-amino-2,3-dihydro-1H-indene-2-carboxylate

: 1092446-07-5
2-cyclobutyloxy-3-methyl-N-(2-trifluoromethanesulfonylaminocarbonyl-indan-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.08 h

1.2: 288 h

2.1: methanol; lithium hydroxide; water / 1,4-dioxane / 20 h

2.2: pH 2

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 192 h

With methanol; dmap; lithium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;