4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Base Information

Chemical Name:4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide
CAS No.:452308-03-1
Molecular Formula:C₁₆H₁₇FN₂O₂S
Molecular Weight:320.388
Hs Code.:

4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2<i>H</i>-benzo[1,2,4]thiadiazine 1,1-dioxide

Synonyms:4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

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Chemical Property of 4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

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Technology Process of 4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

There total 6 articles about 4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 75-07-0,9002-91-9
acetaldehyde

: 714229-62-6
2-benzylamino-5-fluoro-3-methyl-benzenesulfonamide

: 452308-03-1
4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Guidance literature:: With 3 A molecular sieve; camphor-10-sulfonic acid; In acetonitrile; for 5.5h;
DOI:10.1016/S0968-0896(01)00405-9

Reference yield:

: 452-71-1
4-fluor-2-methylaniline

: 452308-03-1
4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1: various solvent(s) / -42 °C

2: aluminium trichloride / various solvent(s) / 2 h / -42 - 110 °C

3: sulfuric acid / water / 2 h / 130 - 140 °C

4: (1S)-10-camphorsulfonic acid / acetonitrile / 24 h

5: sodium cyanoborohydride / tetrahydrofuran; acetic acid / 24 h / 0 °C

6: 3 A molecular sieve; camphor-10-sulfonic acid / acetonitrile / 5.5 h

With aluminium trichloride; 3 A molecular sieve; sulfuric acid; camphor-10-sulfonic acid; (1S)-10-camphorsulfonic acid; sodium cyanoborohydride; In tetrahydrofuran; water; acetic acid; acetonitrile;
DOI:10.1016/S0968-0896(01)00405-9

Reference yield:

: 452307-90-3
2-amino-5-fluoro-3-methyl-benzenesulfonamide

: 452308-03-1
4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: (1S)-10-camphorsulfonic acid / acetonitrile / 24 h

2: sodium cyanoborohydride / tetrahydrofuran; acetic acid / 24 h / 0 °C

3: 3 A molecular sieve; camphor-10-sulfonic acid / acetonitrile / 5.5 h

With 3 A molecular sieve; camphor-10-sulfonic acid; (1S)-10-camphorsulfonic acid; sodium cyanoborohydride; In tetrahydrofuran; acetic acid; acetonitrile;
DOI:10.1016/S0968-0896(01)00405-9