(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

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Chemical Name:(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester
CAS No.:205236-26-6
Molecular Formula:C₄₂H₅₁N₂O₁₀PSi
Molecular Weight:802.934
Hs Code.:

(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Synonyms:(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

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Chemical Property of (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

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Technology Process of (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

There total 7 articles about (S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 990-91-0
dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

: 205236-25-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

: 205236-26-6
(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; for 3h;
DOI:10.1021/jm970853a

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 205236-26-6
(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / DCC, Py / acetonitrile / 18 h / Ambient temperature

2: 98 percent / HCl / dioxane

3: 81 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), i-PrNEt₂ / dimethylformamide / 6 h

4: HCl / dioxane / 2 h

5: i-PrNEt₂ / CH₂Cl₂ / 24 h

6: 88 percent / DBU / CH₂Cl₂ / 3 h

With pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970853a

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 205236-26-6
(S)-2-{(S)-2-Acetylamino-3-[4-(bis-benzyloxy-phosphoryloxy)-phenyl]-propionylamino}-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / DCC, Py / acetonitrile / 18 h / Ambient temperature

2: 98 percent / HCl / dioxane

3: 81 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), i-PrNEt₂ / dimethylformamide / 6 h

4: HCl / dioxane / 2 h

5: i-PrNEt₂ / CH₂Cl₂ / 24 h

6: 88 percent / DBU / CH₂Cl₂ / 3 h

With pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970853a