(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Base Information

Chemical Name:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester
CAS No.:205236-25-5
Molecular Formula:C₂₈H₃₈N₂O₇Si
Molecular Weight:542.704
Hs Code.:

Synonyms:(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

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Chemical Property of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

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Technology Process of (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

There total 5 articles about (S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 205236-25-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / DCC, Py / acetonitrile / 18 h / Ambient temperature

2: 98 percent / HCl / dioxane

3: 81 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), i-PrNEt₂ / dimethylformamide / 6 h

4: HCl / dioxane / 2 h

5: i-PrNEt₂ / CH₂Cl₂ / 24 h

With pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970853a

Reference yield:

: 13574-13-5
Boc-Glu(OBzl)-OH

: 205236-25-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / DCC, Py / acetonitrile / 18 h / Ambient temperature

2: 98 percent / HCl / dioxane

3: 81 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), i-PrNEt₂ / dimethylformamide / 6 h

4: HCl / dioxane / 2 h

5: i-PrNEt₂ / CH₂Cl₂ / 24 h

With pyridine; hydrogenchloride; N,N-diethyl-N-isopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm970853a

Reference yield:

: 172694-24-5
(S)-2-tert-Butoxycarbonylamino-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

: 205236-25-5
(S)-2-[(S)-2-Acetylamino-3-(4-hydroxy-phenyl)-propionylamino]-pentanedioic acid 5-benzyl ester 1-(2-trimethylsilanyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / HCl / dioxane

2: 81 percent / (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), i-PrNEt₂ / dimethylformamide / 6 h

3: HCl / dioxane / 2 h

4: i-PrNEt₂ / CH₂Cl₂ / 24 h

With hydrogenchloride; N,N-diethyl-N-isopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970853a