Technology Process of 3-[(2-aminophenyl)amino]-9-(2-morpholin-4-ylethoxy)-dibenzo[b,e]oxepin-11(6H)-one
There total 1 articles about 3-[(2-aminophenyl)amino]-9-(2-morpholin-4-ylethoxy)-dibenzo[b,e]oxepin-11(6H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3 h / 72 °C
3.1: potassium carbonate / acetone / 4 h / Reflux
4.1: potassium hydroxide / water; methanol / 4 h / 40 °C
5.1: trifluoroacetic anhydride / dichloromethane / 0.5 h / 20 °C
5.2: 0.5 h
6.1: boron tribromide / dichloromethane / -20 °C / Inert atmosphere
7.1: potassium carbonate / acetone / 6 h / Reflux; Inert atmosphere
8.1: caesium carbonate; XPhos; palladium diacetate / 1,4-dioxane; tert-butyl alcohol / 6 h / 110 °C / Inert atmosphere
With
N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); palladium diacetate; boron tribromide; potassium carbonate; caesium carbonate; trifluoroacetic anhydride; potassium hydroxide; XPhos;
In
1,4-dioxane; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1021/jm401276h
