578-22-3

Basic information

• Product Name: 5-HYDROXY-2-METHYL-BENZOIC ACID
• Synonyms: 5-HYDROXY-2-METHYL-BENZOIC ACID;5,2-Cresotic acid;5-hydroxy-2-Methybenzoic acid
• CAS NO: 578-22-3
• Molecular Formula: C₈H₈O₃
• Molecular Weight: 152.14732
• Product Categories: C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 578-22-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 182-187 °C
• Boiling Point: 343.8 °C at 760 mmHg
• Flash Point: 175.9 °C
• Appearance: /
• Density: 1.304
• Vapor Pressure: 2.63E-05mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• PKA: 3.78±0.25(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-HYDROXY-2-METHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-2-METHYL-BENZOIC ACID(578-22-3)
• EPA Substance Registry System: 5-HYDROXY-2-METHYL-BENZOIC ACID(578-22-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 578-22-3(Hazardous Substances Data)

Usage

Uses

5-Hydroxy-2-methylbenzoic acid is used as a pharmaceutical intermediate.

InChI:InChI=1/C8H8O3/c1-5-2-3-6(9)4-7(5)8(10)11/h2-4,9H,1H3,(H,10,11)

Upstream product

• 118-32-1 2-naphthol-6,8-disulfonic acid 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 534-22-5 2-methylfuran 
• 144-55-8 sodium hydrogencarbonate 
• 623-47-2 propynoic acid ethyl ester 
• 118-90-1 ortho-methylbenzoic acid 
• 54811-38-0 5-iodo-2-methylbenzoic?acid 
• 73505-48-3 methyl 3-hydroxy-6-methylbenzoate 
• 471-25-0 Propiolic acid 
• 1975-52-6 5-nitro-o-toluic acid 
• 52008-71-6 1-methyl-4-oxo-2,5-cyclohexadiene-1-carboxylic acid ethyl ester 
• 89106-54-7 6-methyl-3-sulfobenzoic acid 
• 86-65-7 2-aminonaphthalene-6,8-disulfonate 
• 20532-14-3 2-methyl-5-sulfamoyl-benzoic acid 

Downstream Products

• 17522-13-3 2-methyl-6-oxa-bicyclo[3.2.1]oct-2-en-7-one 
• 17522-14-4 5-hydroxy-2-methyl-cyclohex-2-enecarboxylic acid 
• 848685-45-0 2,5-dibromo-2-methylcyclohexanecarboxylic acid 
• 866996-67-0 2,4-dibromo-3-hydroxy-6-methyl-benzoic acid 
• 860752-53-0 3-hydroxy-6-methyl-2-nitro-benzoic acid 
• 199929-14-1 5-hydroxy-2-methyl-4-nitro-benzoic acid 
• 866996-24-9 2,4,5-tribromo-3-hydroxy-6-methyl-benzoic acid 
• 1034026-57-7 (3-chlorophenyl)methyl 5-{[(3-chlorophenyl)methyl]oxy}-2-methylbenzoate 
• 1265287-00-0 methyl 5-methoxy-2-(dibromomethyl)-benzoate 
• 77620-05-4 methyl 5-methoxyl-2-formylbenzoate 
• 73502-03-1 methyl 5-methoxy-2-methyl-benzoate 

Relevant articles and documents

Copper and L-(?)-quebrachitol catalyzed hydroxylation and amination of aryl halides under air

L-(?)-Quebrachitol, a natural product obtained from waste water of the rubber industry, was utilized as an efficient ligand for the copper-catalyzed hydroxylation and amination of aryl halides to selectively give phenols and aryl amines in water or 95percent ethanol. In addition, the hydroxylation of 2-chloro-4-hydroxybenzoic acid was validated on a 100-g scale under air.

METHOD TO PREPARE PHENOLICS FROM BIOMASS

The present invention is directed to a method for preparing a final phenolic product from biomass comprising the steps of providing a furanic compound obtainable from biomass; reacting the furanic compound with a dienophile to obtain a phenolic compound; reacting the phenolic compound further to obtain the final phenolic product.

Synthesis and characterization of π-extended porphyrins as potential precursors for the formation of columnar mesophases: Design principles for columnar mesophases need revision?

A series of meso-a bridged extended porphyrins substituted with long aliphatic chains were synthesized and fully characterized. Two different synthetic strategies were tested to obtain the target structures. The synthetic steps were optimized in order to obtain scalable routes for the production of sufficient quantities of η-extended porphyrins for material science studies. The porphyrins were obtained either as free bases or complexed with Ni II or CuII. UV-Vis spectroscopy and polarized light microscopy was used for the analysis of the material properties of the η-extended porphyrins. The results obtained with our compounds are not compatible with the results reported in the literature. ARKAT-USA, Inc.