3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL

Base Information

• Chemical Name: 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL
• CAS No.: 1645-58-5
• Molecular Formula: C7H13 Br F2 O2
• Molecular Weight: 247.08
• Hs Code.: 2911000000
• Mol file: 1645-58-5.mol

Synonyms:Propionaldehyde,3-bromo-3,3-difluoro-, diethyl acetal (7CI,8CI)

Chemical Property of 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL

Chemical Property:

• Boiling Point: 152.4±40.0 °C(Predicted)
• PSA: 18.46000
• Density: 1.362±0.06 g/cm3(Predicted)
• LogP: 2.76330

Purity/Quality:

99%min ^*data from raw suppliers

3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL

There total 3 articles about 3-BROMO-3,5-DIFLUOROPROPANAL DIETHYL ACETAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethanol (64-17-5) + dibromodifluoromethane (75-61-6) + ethyl vinyl ether (109-92-2,25104-37-4) → Diethyl 3-bromo-3,3-difluoropropanal diethyl acetal (1645-58-5)

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; at 60 ℃; for 5h;

DOI:10.1016/S0022-1139(99)00294-8

Reference yield: 24.32%

dibromodifluoromethane (75-61-6) + ethyl vinyl ether (109-92-2,25104-37-4) → Diethyl 3-bromo-3,3-difluoropropanal diethyl acetal (1645-58-5)

Guidance literature:

With sodium dithionite; sodium hydrogencarbonate; In ethanol; at 60 ℃; for 4h; Sealed tube;

Reference yield:

ethanol (64-17-5) + ethyl-1,3-dibromo-3,3-difluoropropyl ether (1993-81-3) → Diethyl 3-bromo-3,3-difluoropropanal diethyl acetal (1645-58-5)

Guidance literature:

DOI:10.1021/jo01028a051

upstream raw materials:

ethanol

ethyl-1,3-dibromo-3,3-difluoropropyl ether

dibromodifluoromethane

ethyl vinyl ether

Downstream raw materials:

ethyl β,β-difluoroacrylate

ethyl 2-bromo-3,3,3-trifluoropropanoate

ethyl 3,3,3-trifluoropropanoate

Refernces

• 1、 -. "HOT MELT EXTRUDED SOLID DISPERSIONS CONTAINING A BCL2 INHIBITOR". Page/Page column 170. . Retrieved 2021/09/04.
• 2、 Peng, Sheng,Qing, Feng-Ling,Li, Yi-Qun,Hu, Chang-Ming. "Palladium(0)/copper(I)-cocatalyzed cross-coupling of the zinc reagent of ethyl 3-bromo-3,3-difluoropropionate with aryl (alkenyl) halides: An efficient stereoselective synthesis of β-fluoro-α,β-unsaturated esters". . p. 694 - 700. Retrieved 2007/10/03.