[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

Base Information

Chemical Name:[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)
CAS No.:1338582-86-7
Molecular Formula:C₃₆H₅₆N₄O₁₀SSi₂
Molecular Weight:793.098
Hs Code.:

Synonyms:[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

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Chemical Property of [1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

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Technology Process of [1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

There total 3 articles about [1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₈ClN₃O₁₀SSi₂

: 100-46-9
benzylamine

: 1338582-86-7
[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

Guidance literature:: In methanol; dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.017

Reference yield:

: 2873-74-7
gloutaric dichloride

: 1338582-86-7
[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium carbonate / dichloromethane; water / 0.25 h / 8 °C

2: methanol; dichloromethane / 20 °C

With tetrabutylammomium bromide; sodium carbonate; In methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.08.017

Reference yield:

: 141781-17-1
2',5'-bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)pyrimidine

: 1338582-86-7
[1-[2',5'-bis-O-tert-butyldimethylsilyl-β-D-ribofuranosyl]-3-N-(N-benzylaminoglutaryl)thymine]-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; sodium carbonate / dichloromethane; water / 0.25 h / 8 °C

2: methanol; dichloromethane / 20 °C

With tetrabutylammomium bromide; sodium carbonate; In methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.08.017