141781-17-1 Usage
Description
(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine is a complex chemical compound that is a modified form of thymine, one of the four nucleobases found in DNA. (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine features a ribose sugar linked to thymine and is further modified with tert-butyldimethylsilyl groups and a spiro structure containing an amino and oxathiole dioxide moiety. Its intricate structure and specific modifications make it a valuable tool for nucleic acid research and potentially a therapeutic agent.
Uses
Used in Nucleic Acid Research:
(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine is used as a research tool for studying the interactions between nucleic acids and other molecules. Its unique structure allows for the investigation of various biological processes and mechanisms.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine may be utilized as a potential therapeutic agent. Its complex structure and specific modifications could offer new avenues for the development of treatments targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 141781-17-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,1,7,8 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 141781-17:
(8*1)+(7*4)+(6*1)+(5*7)+(4*8)+(3*1)+(2*1)+(1*7)=121
121 % 10 = 1
So 141781-17-1 is a valid CAS Registry Number.
141781-17-1Relevant articles and documents
Novel tsao derivatives modified at positions 3″ and 4″ of the spiro moiety
Lobaton,Velazquez,San-Felix,Chamorro,Tunon,Esteban-Gamboa,De Clercq,Balzarini,Camarasa,Perez-Perez
, p. 675 - 676 (1999)
We have explored the introduction of different functional groups at positions 3″ and 4″ of the spiro moiety of TS AO-T. Alkylation of this spiro moiety afforded mixtures of N and/or C-alkylated derivatives, while acylation occurs, exclusively, on the amino group. Position 3" has been selectively functionalized by halogenation followed by Stille-cross coupling reaction with organostannanes under a variety of experimental conditions. Copyright
TSAO derivatives: Highly specific inhibitors of human immunodeficiency virus type-1 (HIV-1) replication
Camarasa,Perez-Perez,Velazquez,San-Felix,Alvarez,Ingate,Jimeno,Karlsson,De Clercq,Balzarini
, p. 585 - 594 (2007/10/02)
TSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as th
Synthesis of {1-[2',5'-bis-O-(t-butyldimethylsilyl)-β-D-xylo- and β-D-ribofuranosyl]Thymine}-3'-spiro-5''-{4''-amino-1'',2''-oxathiol e-2'',2''-dioxide} (TSAO). A novel type of specific anti-HIV agents
Perez-Perez,San-Felix,Camarasa,Balzarini,De Clercq
, p. 3029 - 3032 (2007/10/02)
Reaction of O-mesylcyanohydrins of furanos-3'-ulosyl thymine with bases afforded β-D-xylo- and ribo-3'-substituted nucleosides. 2'-Deoxygenation of the selectively 5'-O-protected nucleoside gave the ribofuranosyl derivative of thymidine.