2-(Dimethylamino)pyrimidin-4-ol

Base Information

• Chemical Name: 2-(Dimethylamino)pyrimidin-4-ol
• CAS No.: 1635-28-5
• Molecular Formula: C₆H₉N₃O
• Molecular Weight: 139.157
• Hs Code.: 2933599090
• European Community (EC) Number: 848-972-2
• Mol file: 1635-28-5.mol

Synonyms:2-(dimethylamino)pyrimidin-4-ol;1635-28-5;2-(DIMETHYLAMINO)-4(1H)-PYRIMIDINONE;2-(dimethylamino)-1H-pyrimidin-6-one;2-(Dimethylamino)pyrimidin-4(1H)-one;2-(Dimethylamino)-4-hydroxypyrimidine;SCHEMBL803475;SCHEMBL11733533;BAA63528;AKOS010521903;AKOS015909376;AKOS022633807;AT18298;FT-0608792;2-(dimethylamino)-1,4-dihydropyrimidin-4-one;EN300-133807;AB-323/25048236

Chemical Property of 2-(Dimethylamino)pyrimidin-4-ol

Chemical Property:

• Vapor Pressure: 0.00153mmHg at 25°C
• Refractive Index: 1.571
• Boiling Point: 286.5 °C at 760 mmHg
• Flash Point: 127 °C
• PSA: 48.99000
• Density: 1.19 g/cm³
• LogP: -0.16410
• XLogP3: -0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 139.074561919
• Heavy Atom Count: 10
• Complexity: 205

Purity/Quality:

98%Min ^*data from raw suppliers

2-(dimethylamino)pyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=NC=CC(=O)N1

Technology Process of 2-(Dimethylamino)pyrimidin-4-ol

There total 5 articles about 2-(Dimethylamino)pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-benzyloxy-2-dimethylaminopyrimidine (19810-62-9) → 2-Dimethylamino-4-hydroxy-pyrimidin (1635-28-5)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h; under 2250.23 Torr;

DOI:10.1002/chem.201702877

Reference yield:

malic acid (617-48-1,78644-42-5) + N,N-Dimethyl-guanidine (6145-42-2) → 2-dimethylamino-3H-pyrimidin-4-one (1635-28-5)

Guidance literature:

With sulfuric acid; sulfur trioxide;

DOI:10.1021/ja01633a040

Reference yield:

→ 2-Dimethylamino-4-hydroxy-pyrimidin (1635-28-5)

Guidance literature:

5-Brom-2-dimethylamino-4-hydroxypyrimidin (9), H2-Pd/C;

upstream raw materials:

malic acid

N,N-Dimethyl-guanidine

4-benzyloxy-2-dimethylaminopyrimidine

Downstream raw materials:

Dimethyl-(4-{[(E)-methylimino]-phenyl-methyl}-pyrimidin-2-yl)-amine

(2-Dimethylamino-pyrimidin-4-yl)-methylamino-phenyl-acetonitrile

2-(dimethylamino)pyrimidine

N²,N²-dimethyl-5-nitro-pyrimidine-2,4-diamine