4-benzyloxy-2-dimethylaminopyrimidine

Base Information

• Chemical Name: 4-benzyloxy-2-dimethylaminopyrimidine
• CAS No.: 19810-62-9
• Molecular Formula: C₁₃H₁₅N₃O
• Molecular Weight: 229.282
• Mol file: 19810-62-9.mol

Synonyms:

Chemical Property of 4-benzyloxy-2-dimethylaminopyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-2-dimethylaminopyrimidine

There total 3 articles about 4-benzyloxy-2-dimethylaminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-(benzyloxy)-2-chloropyrimidine (108381-28-8) + dimethyl amine (124-40-3) → 4-benzyloxy-2-dimethylaminopyrimidine (19810-62-9)

Guidance literature:

In water; acetonitrile; at 100 ℃; for 1.5h; Autoclave;

DOI:10.1002/chem.201702877

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 4-benzyloxy-2-dimethylaminopyrimidine (19810-62-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Reflux

1.2: 13 h / -50 - 20 °C

2.1: water; acetonitrile / 1.5 h / 100 °C / Autoclave

With potassium tert-butylate; In tetrahydrofuran; water; acetonitrile;

DOI:10.1002/chem.201702877

Reference yield:

→ 4-benzyloxy-2-dimethylaminopyrimidine (19810-62-9)

Guidance literature:

4-Chlor-2-dimethylamino-pyrimidin, Benzylalkohol (Na) (S.2366);

DOI:10.1039/j39680002358

upstream raw materials:

benzyl alcohol

4-(benzyloxy)-2-chloropyrimidine

dimethyl amine

Downstream raw materials:

2-Dimethylamino-4-hydroxy-pyrimidin