(2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester

Base Information

• Chemical Name: (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester
• CAS No.: 1048381-64-1
• Molecular Formula: C₁₉H₁₄Cl₂O₃
• Molecular Weight: 361.224
• Mol file: 1048381-64-1.mol

Synonyms:(2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester

Chemical Property of (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester

There total 1 articles about (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

4-chlorobenzaldehyde (104-88-1) + acetoacetic acid methyl ester (105-45-3) → (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester (1048381-64-1)

Guidance literature:

With piperidine; acetic acid; In benzene; for 24h; Heating;

DOI:10.1016/j.tet.2008.05.122

Reference yield: 83.0%

nitroacetic acid ethyl ester (626-35-7) + (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester (1048381-64-1) → trans-5-[(E)-4-chlorostyryl]-3-(4-chlorophenyl)-2,3-dihydrofuran-2,4-dicarboxylic acid 2-ethyl 4-methyl ester

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1016/j.tet.2008.05.122

Reference yield: 69.0%

nitroacetic acid ethyl ester (626-35-7) + (2E,4E)-2-(4-chlorobenzylidene)-5-(4-chlorophenyl)-3-oxo-4-pentenoic acid methyl ester (1048381-64-1) → (1SR,2RS,6SR)-2,6-bis(4-chlorophenyl)-4-hydroxy-1-nitrocyclohex-3-ene-1,3-dicarboxylic acid 1-ethyl 3-methyl ester + (1RS,2RS,6SR)-2,6-bis(4-chlorophenyl)-4-hydroxy-1-nitrocyclohex-3-ene-1,3-dicarboxylic acid 1-ethyl 3-methyl ester

Guidance literature:

With triethylamine; In chloroform; at 60 ℃; for 14h;

DOI:10.1016/j.tet.2008.05.122

upstream raw materials:

4-chlorobenzaldehyde

acetoacetic acid methyl ester