(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Base Information

Chemical Name:(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester
CAS No.:1424401-85-3
Molecular Formula:C₂₅H₃₃NO₇
Molecular Weight:459.54
Hs Code.:

Synonyms:(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Suppliers and Price of (S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

There total 4 articles about (S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1424401-81-9
6-((S)-4-benzyl-2-oxazolidine-3-yl)-6-hexanoic acid allyl ester

: 1424401-83-1
(R)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

: 1424401-85-3
(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Guidance literature:: 6-((S)-4-benzyl-2-oxazolidine-3-yl)-6-hexanoic acid allyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

bromoacetic acid tert-butyl ester; With sodium iodide; In tetrahydrofuran; at 20 ℃; for 0.5h; Overall yield = 50 %; Overall yield = 1.28 g; stereoselective reaction;
DOI:10.1021/jm301346z

Reference yield:

: 1424401-79-5
6-((S)-4-benzyl-2-oxazolidine-3-yl)-6-hexanoic acid

: 1424401-85-3
(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 64 h / 20 °C / Inert atmosphere

2.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

With sodium hexamethyldisilazane; potassium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm301346z

Reference yield:

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 1424401-85-3
(S)-3-((S)-4-benzyl-2-oxooxazolidine-3-carbonyl)heptanedioic acid 7-allyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 64 h / 20 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

With n-butyllithium; sodium hexamethyldisilazane; potassium hydrogencarbonate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm301346z