2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Base Information

Chemical Name:2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
CAS No.:1332502-85-8
Molecular Formula:C₁₇H₁₃BrClF₃N₄O₂
Molecular Weight:477.668
Hs Code.:

Synonyms:2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Chemical Property of 2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

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Technology Process of 2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

There total 5 articles about 2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1228650-25-6
5-(4-chlorophenyl)-4-[⁽²⁸⁾-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

: 39741-46-3
3-bromo-5-(chloromethyl)-pyridine hydrochloride

: 1332502-85-8
2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 40 - 70 ℃; for 64h;

Reference yield:

: 536-40-3
4-chlorobenzoic acid hydrazide

: 1332502-85-8
2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 50 °C

2.1: sodium hydroxide; water / Reflux

2.2: 20 °C / pH 1

3.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

3.2: 70 °C

4.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

5.1: caesium carbonate / N,N-dimethyl-formamide / 64 h / 40 - 70 °C

With pyridine; methanol; sodium tetrahydroborate; water; caesium carbonate; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1228650-22-3
[3-(4-chlorophenyl)-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]acetic acid

: 1332502-85-8
2-[(5-bromopyridin-3-yl)methyl]-5-(4-chlorophenyl)-4-(3,3,3-trifluoro-2-hydroxypropyl)-2,4-dihydro-3H-1,2,4-triazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0.5 h / 35 °C / Inert atmosphere

1.2: 70 °C

2.1: sodium tetrahydroborate; methanol / 1.5 h / Cooling with ice

3.1: caesium carbonate / N,N-dimethyl-formamide / 64 h / 40 - 70 °C

With pyridine; methanol; sodium tetrahydroborate; caesium carbonate; In N,N-dimethyl-formamide;