N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER

Base Information

• Chemical Name: N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER
• CAS No.: 1604-54-2
• Molecular Formula: C₁₂H₁₂F₃NO₄
• Molecular Weight: 291.227
• Hs Code.: 2924299090
• Mol file: 1604-54-2.mol

Synonyms:L-Tyrosine,N-(trifluoroacetyl)-, methyl ester (9CI); Tyrosine, N-(trifluoroacetyl)-,methyl ester, L- (8CI); N-Trifluoroacetyl-L-tyrosine methyl ester

Chemical Property of N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER

Chemical Property:

• Boiling Point: 148 °C (1 mmHg)
• PSA: 75.63000
• LogP: 1.54570
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER

There total 7 articles about N-TRIFLUOROACETYL-L-TYROSINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

L-Tyr-OMe (1080-06-4) + trifluoroacetic anhydride (407-25-0) → methyl (2,2,2-trifluoroacetyl)-L-tyrosinate (3799-87-9,88494-54-6,1604-54-2)

Guidance literature:

With pyridine; In dichloromethane; at 25 ℃; for 0.0833333h;

DOI:10.1021/acs.jmedchem.1c01444

Reference yield: 93.6%

L-tyrosine methyl ester HCl (3417-91-2) + trifluoroacetic anhydride (407-25-0) → methyl (2,2,2-trifluoroacetyl)-L-tyrosinate (3799-87-9,88494-54-6,1604-54-2)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; Solvent; Reflux;

Reference yield:

L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) → methyl (2,2,2-trifluoroacetyl)-L-tyrosinate (3799-87-9,88494-54-6,1604-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.5M HCl / 2 h / Ambient temperature

2: CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; In dichloromethane;

DOI:10.1016/S0040-4020(01)91564-9

upstream raw materials:

trifluoroacetic acid-methyl ester

L-Tyr-OMe

diazomethane

N-trifluorosulfonyl-L-tyrosine

Downstream raw materials:

3-(3-Fluoro-4-hydroxy-5-nitro-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

3-(3-Amino-5-fluoro-4-hydroxy-phenyl)-2-(2,2,2-trifluoro-acetylamino)-propionic acid methyl ester

N-(trifluoroacetyl)-3,4-dihydroxy-5-fluoro-L-phenylalanine methyl ester

N-(trifluoroacetyl)-3,5-difluoro-L-tyrosine methyl ester