potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

Base Information

Chemical Name:potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide
CAS No.:1428884-68-7
Molecular Formula:C₁₄H₁₆BF₃NO₃*K
Molecular Weight:353.19
Hs Code.:

Synonyms:potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

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Chemical Property of potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

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Technology Process of potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

There total 4 articles about potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1279123-63-5
potassium hydrogenfluoride

: 5419-55-6
Triisopropyl borate

: 99275-47-5
1-(tert-butyloxycarbonyl)-5-methoxyindole

: 1428884-68-7
potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

Guidance literature:: 1-(tert-butyloxycarbonyl)-5-methoxyindole; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

potassium hydrogenfluoride; In methanol; water; at 0 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201802142

Reference yield: 45.0%

: potassium hydrogen difluoride

: 290331-71-4
1-(tert-butoxycarbonyl)-5-methoxy-1H-indol-2-ylboronic acid

: 1428884-68-7
potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

Guidance literature:: In methanol; water; at 0 ℃; for 1h;
DOI:10.1021/ja4017655

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1428884-68-7
potassium (1-((tert-butoxy)carbonyl)-5-methoxy-1H-indol-2-yl)trifluoroboranuide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium; 2,2,6,6-tetramethyl-piperidine / hexane; tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 4 h / 0 °C / Inert atmosphere

With 2,2,6,6-tetramethyl-piperidine; dmap; n-butyllithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1002/chem.201802142