(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

Base Information

Chemical Name:(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate
CAS No.:753488-80-1
Molecular Formula:C₅₀H₆₆O₇
Molecular Weight:779.07
Hs Code.:

Synonyms:(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

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Technology Process of (25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

There total 15 articles about (25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 81658-47-1
(R)-(+)-(3-hydroxy-2-methyl-1-propyl)triphenylphosphonium bromide

: 753488-78-7
3-α-benzoyloxy-4β,7α-dibenzyloxymethoxy-24-nor-5α-cholan-23-al

: 753488-80-1
(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

Guidance literature:: With n-butyllithium; chloro-trimethyl-silane; In tetrahydrofuran;
DOI:10.1016/S0040-4039(03)01598-3

Reference yield:

: 14773-00-3
methyl (5β,7α)-12-hydroxy-3-oxo-cholan-24-oate

: 753488-80-1
(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

Guidance literature:: Multi-step reaction with 10 steps

1.1: t-BuOK; O₂ / 2-methyl-propan-2-ol

1.2: 71 percent / CH₂N₂ / diethyl ether; methanol; CHCl₃

2.1: 83 percent / i-Pr₂NEt / CH₂Cl₂

3.1: 44 percent / NaBH₃CN / CHCl₃; methanol

4.1: SOCl₂; Et₃N / tetrahydrofuran

4.2: 65 percent / RuCl₃*nH₂O; NaIO₄ / tetrahydrofuran

5.1: 75 percent / Cs₂CO₃ / dimethylformamide

6.1: 84 percent / i-Pr₂NEt / CH₂Cl₂

7.1: 95 percent / t-BuOK / 2-methyl-propan-2-ol

8.1: 84 percent / Pb(OAc)4; I₂ / CCl₄ / UV-irradiation

9.1: 94 percent / DMSO; 2,4,6-collidine

10.1: 69 percent / n-BuLi; TMSCl / tetrahydrofuran

With 2,4,6-trimethyl-pyridine; lead(IV) acetate; n-butyllithium; chloro-trimethyl-silane; thionyl chloride; potassium tert-butylate; iodine; oxygen; sodium cyanoborohydride; caesium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; chloroform; N,N-dimethyl-formamide; tert-butyl alcohol; 10.1: Wittig reaction;
DOI:10.1016/S0040-4039(03)01598-3

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 753488-80-1
(25S)-4β,7α-dibenzyloxymethoxy-5α-cholest-23-ene-3α,26-diol 3α-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / diisopropylethylamine / CH₂Cl₂ / 22 h / 20 °C

2: 95 percent / t-BuOK / 2-methyl-propan-2-ol / 2 h / 20 °C

3: 94 percent / I₂; Pb(OAc)4 / CCl₄ / 0.33 h / Irradiation; heating

4: 94 percent / 2,4,6-collidine / dimethylsulfoxide / 0.17 h / 150 °C

5: 69 percent / n-BuLi; TMSCl / hexane; tetrahydrofuran / 3.25 h / -78 - 20 °C

With 2,4,6-trimethyl-pyridine; lead(IV) acetate; n-butyllithium; chloro-trimethyl-silane; potassium tert-butylate; iodine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; 5: Wittig reaction;
DOI:10.1016/j.tet.2004.02.075