4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Base Information

• Chemical Name: 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate
• CAS No.: 151223-91-5
• Molecular Formula: C₁₇H₁₈N₂O₅
• Molecular Weight: 330.34
• Mol file: 151223-91-5.mol

Synonyms:4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Chemical Property of 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate

There total 19 articles about 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol (143191-76-8) + thymin (65-71-4,28806-14-6,691841-57-3) → 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate (151223-91-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; Heating;

DOI:10.1021/ja00046a074

Reference yield: 30.0%

1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol (143191-76-8) + thymin (65-71-4,28806-14-6,691841-57-3) → 2(S)-(O-benzoylmethyl)-4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydrofuran (151223-91-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 11h;

DOI:10.1016/S0040-4020(01)85259-5

Reference yield: 29.0%

1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol (143191-76-8) + 2,4-dihydroxy-5-methylpyrimidine (65-71-4,80289-22-1) → 4(S)-<3,4-dihydro-2,4-dioxo-5-methyl-1(2H)-pyrimidinyl>tetrahydro-2(S)-furanmethanol benzoate (151223-91-5)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

upstream raw materials:

1,4-anhydro-5-O-benzoyl-3-deoxy-2-O-p-toluenesulfonyl-D-ribitol

thymin

2,4-dihydroxy-5-methylpyrimidine

D-xylofuranose

Downstream raw materials:

1-[(3S,5S)-5-(hydroxymethyl)tetrahydrofuran-3-yl]thymine