(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1270077-47-8
Molecular Formula:C₂₈H₃₁ClFN₅O₃
Molecular Weight:540.037
Hs Code.:

Synonyms:(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about (R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1263371-41-0
5'-chloro-N₆-(3-fluorobenzyl)-2,4'-bipyridine-2',6-diamine

: 163438-09-3
(R)-1-Boc-nipecotic acid

: 1270077-47-8
(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: (R)-1-Boc-nipecotic acid; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

5'-chloro-N₆-(3-fluorobenzyl)-2,4'-bipyridine-2',6-diamine; With pyridine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 100-82-3
(3-fluorophenyl)methanamine

: 1270077-47-8
(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 168 h / 115 - 120 °C / Inert atmosphere

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 100 °C

3.1: ammonium hydroxide / water; dimethyl sulfoxide / 21 h / 120 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

With ammonium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 626-05-1
2,6-Dibromopyridine

: 1270077-47-8
(R)-3-[5'-chloro-6-(3-fluorobenzylamino)-[2,4']bipyridinyl-2'-ylcarbamoyl]piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 168 h / 115 - 120 °C / Inert atmosphere

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 3 h / 100 °C

3.1: ammonium hydroxide / water; dimethyl sulfoxide / 21 h / 120 °C

4.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: 0.5 h / 20 °C / Inert atmosphere

With ammonium hydroxide; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; sodium carbonate; N-ethyl-N,N-diisopropylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;