methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester
CAS No.:479198-91-9
Molecular Formula:C₃₄H₄₅N₃O₈S₂Si
Molecular Weight:715.964
Hs Code.:

methanesulfonic acid 2-[5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1<i>H</i>-benzoimidazol-2-yl)-ethyl ester

Synonyms:methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

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Chemical Property of methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

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Technology Process of methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

There total 3 articles about methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-63-0
methanesulfonyl chloride

: 479198-87-3
2-{(S)-2-[(4S,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-hydroxy-ethyl}-benzoimidazole-1-sulfonic acid dimethylamide

: 479198-91-9
methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ol026609h

Reference yield:

: 51-17-2,79351-71-6
benzoimidazole

: 479198-91-9
methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide

2.1: lithium diisopropylamide / tetrahydrofuran; hexane / -50 °C

2.2: tetrahydrofuran; hexane / 20 °C

3.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; sodium hydride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol026609h

Reference yield:

: 349422-98-6
1-(N,N-dimethylsulfamoyl)-benzimidazole

: 479198-91-9
methanesulfonic acid 2-[5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1-(1-dimethylsulfamoyl-1H-benzoimidazol-2-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / -50 °C

1.2: tetrahydrofuran; hexane / 20 °C

2.1: 90 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 °C

With dmap; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol026609h