{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

Base Information

Chemical Name:{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester
CAS No.:454185-97-8
Molecular Formula:C₂₅H₃₆O₅Si
Molecular Weight:444.643
Hs Code.:

{4-[5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

Synonyms:{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

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Chemical Property of {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

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Technology Process of {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

There total 8 articles about {4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 454185-96-7
[4-(2-methoxy-2-oxoethyl)phenyl]boronic acid

: 454185-95-6
5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenol

: 454185-97-8
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: With pyridine; 4 A molecular sieve; copper diacetate; In dichloromethane; at 20 ℃; for 48h;
DOI:10.1021/ol0261635

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 454185-97-8
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / -40 °C

2.1: 85 percent / potassium acetate; PdCl₂(dppf) / dioxane / 80 °C

3.1: diethanolamine / propan-2-ol; diethyl ether

3.2: hydrochloric acid / H₂O; tetrahydrofuran / 20 °C

4.1: 57 percent / copper(II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂ / 48 h / 20 °C

With pyridine; 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 4 A molecular sieve; potassium acetate; copper diacetate; 2,2'-iminobis[ethanol]; In 1,4-dioxane; diethyl ether; dichloromethane; isopropyl alcohol;
DOI:10.1021/ol0261635

Reference yield:

: 2973-78-6
3-bromo-4-hydroxybenzylaldehyde

: 454185-97-8
{4-[5-(tert-butyl-dimethyl-silanyloxymethyl)-2-isopropoxy-phenoxy]-phenyl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 94 percent / potassium carbonate / dimethylsulfoxide / 12 h / 55 °C

2.1: 98 percent / sodium borohydride / tetrahydrofuran; methanol / 2 h / 20 °C

3.1: 95 percent / imidazole / dimethylformamide / 12 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 12 h / -78 - 20 °C

4.2: 82 percent / hydrogen peroxide / tetrahydrofuran / 24 h / 20 °C

5.1: 57 percent / copper(II) acetate; pyridine; molecular sieves 4 Angstroem / CH₂Cl₂ / 48 h / 20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; n-butyllithium; 4 A molecular sieve; copper diacetate; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ol0261635