2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

Base Information

Chemical Name:2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide
CAS No.:1192684-29-9
Molecular Formula:C₂₅H₃₀ClN₅O₂
Molecular Weight:467.998
Hs Code.:

Synonyms:2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

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Chemical Property of 2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

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Technology Process of 2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

There total 4 articles about 2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 236406-55-6
2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester

: 1192686-95-5
2-[3-(3-chlorophenyl)-7-iodo-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

: 1192684-29-9
2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester; 2-[3-(3-chlorophenyl)-7-iodo-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide; With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 80 ℃; for 23h;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield:

: 1192686-95-5
2-[3-(3-chlorophenyl)-7-iodo-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

: 136098-14-1
2,7-diazaspiro[3.5]nonane

: 1192684-29-9
2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: With copper(l) iodide; potassium carbonate; rac-Pro-OH; In dimethyl sulfoxide; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.07.037

Reference yield:

: 2895-21-8
2-chloro-N-isopropylacetamide

: 1192684-29-9
2-[3-(3-chlorophenyl)-7-(2,7-diazaspiro[3.5]non-7-yl)-1-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-(1-methylethyl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,2-dimethoxyethane; N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 0.25 h / 20 °C

2.1: copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 23 h / 80 °C

2.2: 1 h / 0 - 20 °C

With copper(l) iodide; sodium hydride; potassium carbonate; In 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-formamide;