2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane

Base Information

• Chemical Name: 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane
• CAS No.: 236406-55-6
• Molecular Formula: C₁₂H₂₂N₂O₂
• Molecular Weight: 226.319
• Hs Code.: 2933990090
• Mol file: 236406-55-6.mol

Synonyms:1,1-Dimethylethyl2,7-diazaspiro[3.5]nonane-2-carboxylate;

Chemical Property of 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane

Chemical Property:

• Vapor Pressure: 0.000339mmHg at 25°C
• Refractive Index: 1.517
• Boiling Point: 319.425 °C at 760 mmHg
• PKA: 10.78±0.20(Predicted)
• Flash Point: 146.983 °C
• PSA: 41.57000
• Density: 1.089 g/cm³
• LogP: 1.87360
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

2,7-Diazaspiro[3.5]nonane-2-carboxylicacidtert-butylester 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 52-25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane is a reagent use in the synthesis of potent GPR119 agonists.

Technology Process of 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane

There total 1 articles about 2-(tert-Butoxycarbonyl)-2,7-diazaspiro[3.5]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 7-benzyl-2,7-diazaspiro[3.5]nonane-2-carboxylate (929301-99-5) → 2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (236406-55-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 0 - 20 ℃; for 96h; under 760.051 Torr;

Reference yield: 94.22%

2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (236406-55-6) + N-(Benzyloxycarbonyl)azetidin-3-one (105258-93-3) → tert-butyl 7-(1-benzyloxycarbonylazetidin-3-yl)-2,7-diazaspiro[3.5]nonane-2-carboxylate

Guidance literature:

With acetic acid; sodium sulfate; In 1,2-dichloro-ethane; at 65 ℃; for 2h;

Reference yield: 86.0%

2,7-diaza-spiro[3.5]nonane-2-carboxylic acid tert-butyl ester (236406-55-6) + benzoic acid (65-85-0,8013-63-6) → tert-butyl 7-benzoyl-2,7-diazaspiro[3.5]nonane-2-carboxylate

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1016/j.ejmech.2021.113591

upstream raw materials:

tert-butyl 7-benzyl-2,7-diazaspiro[3.5]nonane-2-carboxylate

Downstream raw materials:

tert-butyl 7-(4-(3-(4-cyanophenyl)imidazo[1,2-a]pyridin-6-yl)benzoyl)-2,7-diazaspiro[3.5]nonane-2-carboxylate

4-(6-(4-(2,7-diazaspiro[3.5]nonane-7-carbonyl)phenyl)imidazo[1,2-a]pyridin-3-yl)benzonitrile

2-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-7-carboxylic acid pyridin-3-ylamide

7-[3-(4-chloro-phenoxy)-benzyl]-2,7-diaza-spiro[3.5]nonane-2-carboxylic acid (6-[1,2,3]triazol-2-yl-pyridin-3-yl)-amide