2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

Base Information

Chemical Name:2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide
CAS No.:33213-50-2
Molecular Formula:C₁₉H₁₇Cl₃N₂O₆S
Molecular Weight:507.779
Hs Code.:

Synonyms:2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

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Chemical Property of 2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

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Technology Process of 2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

There total 3 articles about 2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 24689-52-9
2,2,2-trichloroethyl 7β-phenoxyacetamido-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 33213-50-2
2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

Guidance literature:: With dibenzylammonium trifluoroacetate salt; In dichloromethane; butan-1-ol; for 24h; Heating;

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 27250-45-9
(6R)-3-methyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester

: 33213-50-2
2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

Guidance literature:: With N,N-dimethylammonium chloride; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm00287a011

Reference yield:

: 24647-47-0
2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate

: 33213-50-2
2,2,2-trichloroethyl 7β-phenoxyacetamido-2-methylene-3-methyl-3-cephem-4-carboxylate 1S-(β)-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 3 h / 0 °C

2: 95 percent / dibenzylamine trifluoroacetate / CH₂Cl₂; butan-1-ol / 24 h / Heating

With 3-chloro-benzenecarboperoxoic acid; dibenzylammonium trifluoroacetate salt; In dichloromethane; butan-1-ol;