3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one

Base Information

• Chemical Name: 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one
• CAS No.: 1334474-13-3
• Molecular Formula: C₂₁H₁₇NO₃
• Molecular Weight: 331.371
• Mol file: 1334474-13-3.mol

Synonyms:3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one

Chemical Property of 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one

There total 7 articles about 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-acetyl-3-benzyl-3a,8a-dihydroxy-2-methyl-3a,8a-dihydro-3-azacyclopenta[a]inden-8-one → 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one (1334474-13-3)

Guidance literature:

With sulfuric acid; acetic acid; at 85 ℃; for 0.0833333h;

DOI:10.1016/j.tetlet.2011.07.133

Reference yield: 95.0%

indan-1,2,3-trione hydrate (485-47-2) + acetylacetone (123-54-6,81235-32-7) + benzylamine (100-46-9) → 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one (1334474-13-3)

Guidance literature:

With montrmorillonite K₁₀; for 0.0233333h; Microwave irradiation;

DOI:10.1039/c4ra02792b

Reference yield: 88.0%

C14H12O5 + benzylamine (100-46-9) → 3-acetyl-1-benzyl-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one (1334474-13-3)

Guidance literature:

With silica sulfuric acid; In neat (no solvent, solid phase); at 65 ℃; for 1h; Catalytic behavior; Mechanism;

DOI:10.3762/bjoc.9.269

upstream raw materials:

4-benzylaminopent-3-en-2-one

acetylacetone

benzylamine

indan-1,2,3-trione hydrate