(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

Base Information

Chemical Name:(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol
CAS No.:211053-75-7
Molecular Formula:C₂₁H₃₂O₂
Molecular Weight:316.484
Hs Code.:

Synonyms:(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

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Chemical Property of (-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

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Technology Process of (-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

There total 8 articles about (-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 211053-74-6
[(3S,4aR,6aS,10aS,10bS)-decahydro-7,7,10a-trimethyl-1H-naphtho[2,1-d][1,3]dioxin-3-yl]benzene

: 211053-75-7
(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

: (+)-(1R,2R,4aS,8aS)-1-benzyloxy-2-hydroxydecahydro-5,5,8a-trimethylnaphthalene

Guidance literature:: With lithium aluminium tetrahydride; aluminium trichloride; In diethyl ether; at -20 ℃; for 0.5h;
DOI:10.1016/S0957-4166(98)00172-4

Reference yield:

: 59633-91-9,65754-93-0,108944-87-2,108944-88-3,136982-34-8,146611-16-7,807360-95-8
rac-12-nor-drimane-8α,11-diol

: 211053-75-7
(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / conc. H₂SO₄ / dimethylsulfoxide / 1 h / Ambient temperature

2: 99 percent / p-dimethylaminopyridine, pyridine / 1 h / Ambient temperature

4: 96 percent / H₂ / 20percent Pd(OH)2-C / methanol / Ambient temperature

5: 98 percent / conc. H₂SO₄ / dimethylsulfoxide / 0.5 h / Ambient temperature

6: 93 percent / LiAlH₄, AlCl₃ / diethyl ether / 0.5 h / -20 °C

With pyridine; dmap; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen; palladium hydroxide - carbon; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00172-4

Reference yield:

: 1-((3R,4aS,6aR,10aR,10bR)-7,7,10a-Trimethyl-decahydro-naphtho[2,1-d][1,3]dioxin-3-yl)-naphthalen-2-ol

: 211053-75-7
(-)-(1S,2R,4aS,8aS)-2-benzyloxydecahydro-5,5,8a-trimethyl-1-naphthylmethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / p-dimethylaminopyridine, pyridine / 1 h / Ambient temperature

3: 96 percent / H₂ / 20percent Pd(OH)2-C / methanol / Ambient temperature

4: 98 percent / conc. H₂SO₄ / dimethylsulfoxide / 0.5 h / Ambient temperature

5: 93 percent / LiAlH₄, AlCl₃ / diethyl ether / 0.5 h / -20 °C

With pyridine; dmap; lithium aluminium tetrahydride; aluminium trichloride; sulfuric acid; hydrogen; palladium hydroxide - carbon; In methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(98)00172-4