(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione
CAS No.:1400903-27-6
Molecular Formula:C₂₆H₂₇F₃N₂O₃
Molecular Weight:472.507
Hs Code.:

Synonyms:(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

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Chemical Property of (E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

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Technology Process of (E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

There total 7 articles about (E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400903-25-4
(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

: 1400903-27-6
(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 121h;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1400903-27-6
(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 1.5 h / 20 °C

1.3: 1.5 h / Reflux

2.1: piperidine; acetic acid / toluene / 48 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

4.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

4.2: 1.5 h / 0 °C / Reflux

5.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 42.42 h / 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 121 h

With piperidine; dmap; tetrabutyl ammonium fluoride; hydrogen; sodium; sodium hydride; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 95233-37-7,49708-81-8,1346600-43-8
(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

: 1400903-27-6
(E)-3-(2-hydroxy-ethyl)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

1.2: 16 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

2.2: 1.5 h / 20 °C

2.3: 1.5 h / Reflux

3.1: piperidine; acetic acid / toluene / 48 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

5.2: 1.5 h / 0 °C / Reflux

6.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 42.42 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 121 h

With piperidine; dmap; tetrabutyl ammonium fluoride; hydrogen; sodium; sodium hydride; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;