(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

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Chemical Name:(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione
CAS No.:1400903-25-4
Molecular Formula:C₃₂H₄₁F₃N₂O₃Si
Molecular Weight:586.77
Hs Code.:

Synonyms:(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

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Chemical Property of (E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

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Technology Process of (E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

There total 7 articles about (E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400902-13-7
(E)-6-(4-phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione

: 86864-60-0
2-(tert-butyldimethylsilyloxy)ethyl bromide

: 1400903-25-4
(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 42.4167h;

Reference yield:

: 1466-73-5
trans-4-phenylcyclohexanecarboxylic acid

: 1400903-25-4
(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

1.2: 1.5 h / 20 °C

1.3: 1.5 h / Reflux

2.1: piperidine; acetic acid / toluene / 48 h / Reflux

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

4.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

4.2: 1.5 h / 0 °C / Reflux

5.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 42.42 h / 20 °C

With piperidine; dmap; hydrogen; sodium; sodium hydride; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 95233-37-7,49708-81-8,1346600-43-8
(+/-)-trans-4-(4-chlorophenyl)cyclohexane carboxylic acid

: 1400903-25-4
(E)-3-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-6-(4-phenylcyclohexyl)-5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

1.2: 16 h / 20 °C

1.3: 0.25 h

2.1: dmap / dichloromethane / 0.17 h / 20 °C / Molecular sieve

2.2: 1.5 h / 20 °C

2.3: 1.5 h / Reflux

3.1: piperidine; acetic acid / toluene / 48 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

5.1: sodium / ethanol / 1 h / Inert atmosphere; Reflux

5.2: 1.5 h / 0 °C / Reflux

6.1: chloroacetic acid / 1,4-dioxane; water / 64 h / 100 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 42.42 h / 20 °C

With piperidine; dmap; hydrogen; sodium; sodium hydride; acetic acid; chloroacetic acid; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;