AC-VAL-OME

Base Information

• Chemical Name: AC-VAL-OME
• CAS No.: 1492-15-5
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Hs Code.: 2924199090
• Mol file: 1492-15-5.mol

Synonyms:Valine,N-acetyl-, methyl ester, L- (8CI);L-N-Acetylvaline methyl ester;Methyl N-acetyl-L-valinate;N-Acetyl-L-valine methyl ester;N-Acetylvaline methyl ester;

Chemical Property of AC-VAL-OME

Chemical Property:

• Melting Point: 61.3-62.5 °C
• Boiling Point: 275.4 °C at 760 mmHg
• PKA: 14.70±0.46(Predicted)
• Flash Point: 120.4 °C
• PSA: 55.40000
• Density: 1.014 g/cm³
• LogP: 0.71100
• Storage Temp.: Store at RT.

Purity/Quality:

99% ^*data from raw suppliers

methylN-acetylvalinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AC-VAL-OME

There total 30 articles about AC-VAL-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-acetamido-3-methylbut-2-enoate (39239-88-8) → N-acetyl-DL-valine methyl ester (52152-47-3,1492-12-2,1492-15-5,90243-89-3)

Guidance literature:

With hydrogen; iridium; In dichloromethane; at 19.9 ℃; for 0.00416667h;

Reference yield: 100.0%

methyl 2-acetamido-3-methylbut-2-enoate (39239-88-8) → (S)-N-acetylvaline methyl ester (1492-15-5)

Guidance literature:

With Rh⁽¹⁺⁾*2CH₄O*C₄H₁₂B^(1-)*C₃₄H₄₀O₂P₂; hydrogen; In methanol; at 22 ℃; for 2h; under 2250.23 Torr; enantioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.201200780

Reference yield: 100.0%

L-Valine methyl ester (4070-48-8) + acetic anhydride (108-24-7) → (S)-N-acetylvaline methyl ester (1492-15-5)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

DOI:10.1002/ejoc.200900271

upstream raw materials:

L-valine methylester hydrochloride

acetic anhydride

dimethyl malonate sodium salt

(S)-2-Chloro-5-isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazine

Downstream raw materials:

N-acetyl-D-valine

N-acetyl-L-valine

N-acetyl-L-valinamide

L-valine

Refernces

• 1、 -. "Desulfurization method of organic compounds containing mercapto or disulfide bond". Paragraph 0026. . Retrieved 2019/10/01.
• 2、 Ticconi, Barbara,Colcerasa, Arianna,Di Stefano, Stefano,Lanzalunga, Osvaldo,Lapi, Andrea,Mazzonna, Marco,Olivo, Giorgio. "Oxidative functionalization of aliphatic and aromatic amino acid derivatives with H2O2 catalyzed by a nonheme imine based iron complex". . p. 19144 - 19151. Retrieved 2018/05/31.