4-Benzyloxybenzoic acid anhydride

Base Information

• Chemical Name: 4-Benzyloxybenzoic acid anhydride
• CAS No.: 1486-49-3
• Molecular Formula: C28H22 O5
• Molecular Weight: 438.48
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID80564231
• Wikidata: Q82448856
• Mol file: 1486-49-3.mol

Synonyms:4-benzyloxybenzoic acid anhydride;1486-49-3;4-(Benzyloxy)benzoic anhydride;(4-phenylmethoxybenzoyl) 4-phenylmethoxybenzoate;Benzoic acid, 4-(phenylmethoxy)-, anhydride with 4-(phenylmethoxy)benzoic acid;4-BENZYLOXYBENZOICACIDANHYDRIDE;4-benzyloxybenzoic anhydride;SCHEMBL4059146;DTXSID80564231

Chemical Property of 4-Benzyloxybenzoic acid anhydride

Chemical Property:

• Melting Point: 118-119 °C
• Boiling Point: 625.9±50.0 °C(Predicted)
• PSA: 61.83000
• Density: 1.231±0.06 g/cm3(Predicted)
• LogP: 5.84180
• XLogP3: 6.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 10
• Exact Mass: 438.14672380
• Heavy Atom Count: 33
• Complexity: 539

Purity/Quality:

99% ^*data from raw suppliers

4-BENZYLOXYBENZOIC ACID ANHYDRIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=C(C=C2)C(=O)OC(=O)C3=CC=C(C=C3)OCC4=CC=CC=C4

Technology Process of 4-Benzyloxybenzoic acid anhydride

There total 6 articles about 4-Benzyloxybenzoic acid anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxy)benzoic acid chloride (1486-50-6) + 3'-benzyloxy-2'-hydroxy-6'-isopropoxy-4',5'-dimethylacetophenone (169130-27-2) → p-(benzyloxy)benzoic acid anhydride (1486-49-3) + 4-Benzyloxy-benzoic acid 2-acetyl-6-benzyloxy-3-isopropoxy-4,5-dimethoxy-phenyl ester

Guidance literature:

In pyridine; at 50 - 80 ℃; for 2h;

DOI:10.1016/0031-9422(95)00070-N

Reference yield:

4-(benzyloxy)benzoic acid chloride (1486-50-6) → p-(benzyloxy)benzoic acid anhydride (1486-49-3)

Guidance literature:

With pyridine; anschliessend Behandeln mit wss. HCl und Eis;

DOI:10.1016/0040-4020(58)88011-4

Reference yield:

p-(benzyloxy)benzoic acid (1486-51-7) → p-(benzyloxy)benzoic acid anhydride (1486-49-3)

Guidance literature:

With pyridine; thionyl chloride; diethyl ether;

upstream raw materials:

4-(benzyloxy)benzoic acid chloride

p-(benzyloxy)benzoic acid

3'-benzyloxy-2'-hydroxy-6'-isopropoxy-4',5'-dimethylacetophenone

Ethyl 4-hydroxybenzoate

Downstream raw materials:

4'-(benzyloxy)-5,7-dihydroxy-3-methoxyflavone

4′-O-benzylapigenin

2-(4-benzyloxy-phenyl)-6-hydroxy-3,5,7-trimethoxy-chromen-4-one

2-(4-Benzyloxy-phenyl)-5,6-dihydroxy-3,7-dimethoxy-chromen-4-one