(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

Base Information

Chemical Name:(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol
CAS No.:1352571-30-2
Molecular Formula:C₂₂H₂₄N₂O₅
Molecular Weight:396.443
Hs Code.:

Synonyms:(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

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Technology Process of (S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

There total 9 articles about (S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352571-29-9
(S)-3-(1-(tert-butyldimethylsilyloxy)propan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

: 1352571-30-2
(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 136-36-7
benzoate d'hydroxy-3 phenyle

: 1352571-30-2
(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 - 20 °C

2.2: 1 h / 0 °C / Reflux

3.1: 1H-imidazole / dichloromethane / 0.75 h / 0 - 20 °C

4.1: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 10 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

5.1: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; water; sodium carbonate; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; acetonitrile; 1.1: Mitsunobu reaction / 5.1: Suzuki Coupling;

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 1352571-30-2
(S)-3-(1-hydroxypropan-2-yloxy)-5-(4-(4-methoxybenzyloxy)-5-methylpyrimidin-2-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / toluene / 2.5 h / -25 °C

2: water; sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / acetonitrile / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With tetrabutyl ammonium fluoride; water; sodium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; toluene; acetonitrile; 2: Suzuki Coupling;