5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon

Base Information

• Chemical Name: 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon
• CAS No.: 71741-92-9
• Molecular Formula: C₁₇H₁₂F₂O₂
• Molecular Weight: 286.278
• Mol file: 71741-92-9.mol

Synonyms:5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon

Chemical Property of 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon

There total 2 articles about 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4,4'-Difluorobenzophenone (345-92-6) + ethyl 2-bromomethyl-2-propenoate (17435-72-2) → 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon (71741-92-9)

Guidance literature:

With zinc; In tetrahydrofuran; for 2h; Heating;

DOI:10.1002/ardp.19933260508

Reference yield: 45.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5,5-Bis-(4-fluorphenyl)-2-oxo-4,5-dihydro-3H-furan-3-carbonsaeure (149530-23-4) → 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon (71741-92-9)

Guidance literature:

With sodium acetate; diethylamine; In water; acetic acid; 1) r.t., 5 min, 2) 100 deg C, 10 min;

DOI:10.1002/ardp.19933260508

Reference yield: 80.0%

4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) + 5,5-Bis-(4-fluorphenyl)-3-methylen-4,5-dihydro-2(3H)-furanon (71741-92-9) → (+/-)-5,5-bis-(4-fluorophenyl)-3-<4-(2-oxo-1-benzimidazolinyl)-piperidinomethyl>-4,5-dihydro-2(3H)-furanon (153530-61-1,153530-62-2,148903-29-1)

Guidance literature:

With acetic acid; In diethyl ether; ethanol; for 48h; Ambient temperature;

DOI:10.1002/ardp.19933260508

upstream raw materials:

formaldehyd

5,5-Bis-(4-fluorphenyl)-2-oxo-4,5-dihydro-3H-furan-3-carbonsaeure

4,4'-Difluorobenzophenone

ethyl 2-bromomethyl-2-propenoate

Downstream raw materials:

(+/-)-5,5-bis-(4-fluorophenyl)-3-<4-(2-oxo-1-benzimidazolinyl)-piperidinomethyl>-4,5-dihydro-2(3H)-furanon