N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Base Information

• Chemical Name: N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide
• CAS No.: 1610875-66-5
• Molecular Formula: C₁₇H₁₇BrClNO₃
• Molecular Weight: 398.684
• Mol file: 1610875-66-5.mol

Synonyms:N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Chemical Property of N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide

There total 1 articles about N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-chloro-benzeneacetic acid (2444-36-2) + 4-bromo-2-(2-methoxyethoxy)aniline (1219730-72-9) → N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-66-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 29.0%

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole-1-carboxylate (552846-17-0) + N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-66-5) → tert-butyl 4-(4-(2-(2-chlorophenyl)acetamido)-3-(2-methoxyethoxy)phenyl)-1H-pyrazole-1-carboxylate (1610875-67-6)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 70 ℃; for 1h; Inert atmosphere;

Reference yield:

N-(4-bromo-2-(2-methoxyethoxy)phenyl)-2-(2-chlorophenyl)acetamide (1610875-66-5) → 2-(2-chlorophenyl)-N-(2-(2-methoxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide (1610875-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / 1,4-dioxane; water / 1 h / 70 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1.5 h / 40 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water;

upstream raw materials:

2'-chloro-benzeneacetic acid

4-bromo-2-(2-methoxyethoxy)aniline

Downstream raw materials:

tert-butyl 4-(4-(2-(2-chlorophenyl)acetamido)-3-(2-methoxyethoxy)phenyl)-1H-pyrazole-1-carboxylate

2-(2-chlorophenyl)-N-(2-(2-methoxyethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide