1-Methyl-5-(4-pyridinyl)indoline

Base Information

• Chemical Name: 1-Methyl-5-(4-pyridinyl)indoline
• CAS No.: 1453-83-4
• Molecular Formula: C₁₄H₁₄N₂
• Molecular Weight: 210.279
• DSSTox Substance ID: DTXSID40590753
• Wikidata: Q82484395
• Mol file: 1453-83-4.mol

Synonyms:1-Methyl-5-(4-pyridinyl)indoline;1453-83-4;1-methyl-5-pyridin-4-yl-2,3-dihydroindole;1-Methyl-5-(pyridin-4-yl)-2,3-dihydro-1H-indole;DTXSID40590753;DB-301520

Chemical Property of 1-Methyl-5-(4-pyridinyl)indoline

Chemical Property:

• Vapor Pressure: 3.25E-06mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 387.6°Cat760mmHg
• Flash Point: 188.2°C
• PSA: 16.13000
• Density: 1.117g/cm³
• LogP: 2.80590
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 210.115698455
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

99% ^*data from raw suppliers

1-METHYL-5-(4-PYRIDINYL)INDOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC2=C1C=CC(=C2)C3=CC=NC=C3

Technology Process of 1-Methyl-5-(4-pyridinyl)indoline

There total 4 articles about 1-Methyl-5-(4-pyridinyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-methyl-5-(1-trifluoromethanesulfonyl-1,4-dihydro-pyridin-4-yl)-2,3-dihydro-1H-indole (871122-88-2) → 1-methyl-5-pyridin-4-yl-2,3-dihydro-1H-indole (1453-83-4)

Guidance literature:

With potassium tert-butylate; In dimethyl sulfoxide; at 23 ℃; for 0.5h;

DOI:10.1021/ol052476z

Reference yield:

pyridine (110-86-1) → 1-methyl-5-pyridin-4-yl-2,3-dihydro-1H-indole (1453-83-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 0.08 h / -30 °C

2: 84 percent / CH₂Cl₂ / 0.5 h / -30 °C

3: 100 percent / tert-BuOK / dimethylsulfoxide / 0.5 h / 23 °C

With potassium tert-butylate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ol052476z

Reference yield:

N-(trifluoromethylsulfonyl)pyridinium trifluoromethanesulfonate → 1-methyl-5-pyridin-4-yl-2,3-dihydro-1H-indole (1453-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / CH₂Cl₂ / 0.5 h / -30 °C

2: 100 percent / tert-BuOK / dimethylsulfoxide / 0.5 h / 23 °C

With potassium tert-butylate; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ol052476z

upstream raw materials:

1-methyl-5-(1-trifluoromethanesulfonyl-1,4-dihydro-pyridin-4-yl)-2,3-dihydro-1H-indole

pyridine