(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

Base Information

Chemical Name:(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate
CAS No.:1300006-84-1
Molecular Formula:C₂HF₃O₂*C₂₄H₂₃F₃N₄O₃
Molecular Weight:586.491
Hs Code.:

Synonyms:(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

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Chemical Property of (R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

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Technology Process of (R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

There total 5 articles about (R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride

: 76-05-1
trifluoroacetic acid

: 124980-94-5
(2R)-3-(4-fluorophenyl)-2-hydroxypropanoic acid

: 1300006-84-1
(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

Guidance literature:: (S)-2-amino-N-(6-amino-pyridin-3-ylmethyl)-3-(3,4-difluoro-phenyl)-propionamide dihydrochloride; (2R)-3-(4-fluorophenyl)-2-hydroxypropanoic acid; With benzotriazol-1-ol; In dichloromethane; at 0 ℃; for 0.25h;

With triethylamine; In dichloromethane; at 0 ℃; for 18h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 18125-46-7
(R)-4-fluorophenylalanine

: 1300006-84-1
(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium nitrite; sulfuric acid / water / 0 - 20 °C / Cooling with ice

2.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

2.2: 18 h / 0 °C

With sulfuric acid; benzotriazol-1-ol; sodium nitrite; In dichloromethane; water;

Reference yield:

: 4214-73-7
6-aminonicotinonitrile

: 1300006-84-1
(R)-N-[(S)-1-[(6-amino-pyridin-3-ylmethyl)-carbamoyl]-2-(3,4-difluoro-phenyl)-ethyl]-3-(4-fluoro-phenyl)-2-hydroxy-propionamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water / 18 h / 517.16 Torr

2.1: benzotriazol-1-ol / dichloromethane; N,N-dimethyl-formamide / 0.25 h / 0 °C

2.2: 5 h / 0 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: benzotriazol-1-ol / dichloromethane / 0.25 h / 0 °C

4.2: 18 h / 0 °C

With hydrogenchloride; hydrogen; benzotriazol-1-ol; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;