4214-73-7

Basic information

• Product Name: 2-Amino-5-cyanopyridine
• Synonyms: TIMTEC-BB SBB004293;2-AMINO-5-CYANOPYRIDINE;6-AMINONICOTINONITRILE;6-AMINO-3-PYRIDINECARBONITRILE;5-Cyano-2-pyridinamine;2-Amino-5-cyanopyridine, 6-Aminonicotinonitrile;2-Aminopyridine-5-carbonitrile;6-Amino-Nicotinontrile (6-Amino-3-Cyano Pyridine)
• CAS NO: 4214-73-7
• Molecular Formula: C₆H₅N₃
• Molecular Weight: 119.12
• EINECS: -0
• Product Categories: Pyridine series;Amines;Pyridines;Pyridine;Heterocyclic Compounds;Heterocycle-Pyridine series
• Mol File: 4214-73-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 159-163 °C(lit.)
• Boiling Point: 240-250°C 15mm
• Flash Point: 240-250°C/15mm
• Appearance: Brown/Crystalline Powder
• Density: 1.23 g/cm³
• Vapor Pressure: 0.000966mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.48±0.13(Predicted)
• Water Solubility: Soluble in methanol. Insoluble in water.
• BRN: 113876
• CAS DataBase Reference: 2-Amino-5-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-5-cyanopyridine(4214-73-7)
• EPA Substance Registry System: 2-Amino-5-cyanopyridine(4214-73-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 36-26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• F: 10-23
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4214-73-7(Hazardous Substances Data)

Usage

Chemical Properties

brown crystalline powder

Uses

2-Amino-5-cyanopyridine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

InChI:InChI=1/C6H5N3/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,(H2,8,9)/p+1

Upstream product

• 69045-78-9 2-chloro-5-(Trichloromethyl)-pyridine 

Downstream Products

• 847154-25-0 6-(4-nitro-benzenesulfonylamino)-nicotinonitrile 
• 3167-49-5 6-aminonicotinic acid 
• 329-89-5 6-aminonicotinic amide 
• 94805-52-4 6-hydroxy-3-pyridinecarbonitrile 
• 181305-28-2 1-[2-(2-Chloro-3-ethoxy-6-fluoro-phenyl)-ethyl]-3-(5-cyano-pyridin-2-yl)-thiourea 
• 181305-34-0 1-[2-(2-Cyano-6-fluoro-3-methoxy-phenyl)-ethyl]-3-(5-cyano-pyridin-2-yl)-thiourea 
• 156361-02-3 2-amino-3-chloro-5-cyanopyridine 
• 845878-68-4 6-(4-nitro-benzenesulfonylamino)-nicotinic acid amide 
• 862011-06-1 phenyl (5-cyanopyridin-2-yl)carbamate 
• 928782-83-6 N-(5-cyano-2-pyridyl)-4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydroisoxazole-3-yl]-2-methyl benzoic acid amide 
• 1187322-51-5 6-amino-5-iodo-3-pyridinecarbonitrile 
• 1207830-40-7 (2S)-3-(2-(tert-butyldiphenylsilyloxy)ethoxy)-N-(5-cyanopyridin-2-yl)-2-(1-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)propanamide 
• 1228304-19-5 2-(4-bromophenyl)imidazo[1,2-a]pyridine-6-carbonitrile hydrobromide 
• 1441876-26-1 6-(benzylamino)-N'-hydroxynicotinimidamide 

Relevant articles and documents

PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).