2-bromo-3-methylpropiophenone

Base Information

• Chemical Name: 2-bromo-3-methylpropiophenone
• CAS No.: 1451-83-8
• Molecular Formula: C10H11 Br O
• Molecular Weight: 227.101
• Hs Code.: 2914700090
• Mol file: 1451-83-8.mol

Synonyms:Propiophenone,2-bromo-3'-methyl- (7CI,8CI)

Chemical Property of 2-bromo-3-methylpropiophenone

Chemical Property:

• Boiling Point: 134-135 °C(Press: 8 Torr)
• PSA: 17.07000
• Density: 1.357±0.06 g/cm3(Predicted)
• LogP: 2.96110

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-1-(3-methylphenyl)propan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-3-methylpropiophenone

There total 3 articles about 2-bromo-3-methylpropiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3'-Methylpropiophenone (51772-30-6) → 2-bromo-1-(3-methylphenyl)propan-1-one (1451-83-8)

Guidance literature:

With bromine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1021/ml500113s

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → 2-bromo-1-(3-methylphenyl)propan-1-one (1451-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane

2: bromine / dichloromethane

With aluminum (III) chloride; bromine; In dichloromethane; 1: |Friedel-Crafts Acylation;

DOI:10.3390/ijms20071524

Reference yield:

→ 2-bromo-1-(3-methylphenyl)propan-1-one (1451-83-8)

Guidance literature:

m-Methylpropiophenon in Dioxan/Ae., Brom;

upstream raw materials:

3'-Methylpropiophenone

toluene

Downstream raw materials:

2-(methylamino)-1-(3-methylphenyl)propan-1-one hydrochloride

PAL-589

2-(N-cyclopentylamino)-3'-methylpropiophenone

2-(N-pyrrolidinyl)-3'-methylpropiophenone

Refernces

• 1、 Ouyang, Xuan-Hui,Hu, Chao,Song, Ren-Jie,Li, Jin-Heng. "Annulation Cascades of 2-Bromo-1-arylpropan-1-ones with Terminal Alkynes Involving C-Br/C-H Functionalization". supporting information. p. 4659 - 4662. Retrieved 2018/08/09.
• 2、 Blough, Bruce E.,Landavazo, Antonio,Partilla, John S.,Baumann, Michael H.,Decker, Ann M.,Page, Kevin M.,Rothman, Richard B.. "Hybrid dopamine uptake blocker-serotonin releaser ligands: A new twist on transporter-focused therapeutics". supporting information. p. 623 - 627. Retrieved 2014/07/07.