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| CAS No.: | 1451-83-8 |
|---|---|
| Name: | 2-bromo-3-methylpropiophenone |
| Molecular Structure: | |
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| Formula: | C10H11 Br O |
| Molecular Weight: | 227.101 |
| Synonyms: | Propiophenone,2-bromo-3'-methyl- (7CI,8CI) |
| Density: | 1.357±0.06 g/cm3(Predicted) |
| Boiling Point: | 134-135 °C(Press: 8 Torr) |
| PSA: | 17.07000 |
| LogP: | 2.96110 |

3'-Methylpropiophenone


2-bromo-1-(3-methylphenyl)propan-1-one

| Conditions | Yield |
|---|---|
| With bromine In dichloromethane at 20℃; for 0.5h; | 100% |
| With bromine In dichloromethane for 10h; Inert atmosphere; | 59% |
| Stage #1: 3'-Methylpropiophenone With bromine In dichloromethane for 10h; Inert atmosphere; Stage #2: In dichloromethane | 59% |

| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane 2: bromine / dichloromethane View Scheme |

2-bromo-1-(3-methylphenyl)propan-1-one


tert-butylamine


2-(N-tert-butylamino)-3'-methylpropiophenone

| Conditions | Yield |
|---|---|
| at 70℃; for 2h; | 98% |
| at 70℃; for 2h; | 98% |

| Conditions | Yield |
|---|---|
| With 1,10-Phenanthroline; tetrakis(actonitrile)copper(I) hexafluorophosphate; potassium carbonate In toluene at 120℃; for 16h; Schlenk technique; Inert atmosphere; | 63% |
| With 1,10-Phenanthroline; tetrakis(actonitrile)copper(I) hexafluorophosphate; potassium carbonate In toluene at 120℃; for 16h; Schlenk technique; Sealed tube; Inert atmosphere; | 63% |

| Conditions | Yield |
|---|---|
| In tetrahydrofuran at 50℃; for 18h; Sealed tube; | 45% |

| Conditions | Yield |
|---|---|
| In acetonitrile at 20 - 40℃; Inert atmosphere; | 20% |

| Conditions | Yield |
|---|---|
| In acetonitrile at 20℃; for 7h; |

2-bromo-1-(3-methylphenyl)propan-1-one

| Conditions | Yield |
|---|---|
| With sodium tetrahydroborate In methanol |

pyrrolidine


2-bromo-1-(3-methylphenyl)propan-1-one


2-(N-pyrrolidinyl)-3'-methylpropiophenone

| Conditions | Yield |
|---|---|
| In water; acetonitrile at 20℃; for 4h; |

2-bromo-1-(3-methylphenyl)propan-1-one


Cyclopentamine


2-(N-cyclopentylamino)-3'-methylpropiophenone

| Conditions | Yield |
|---|---|
| In acetonitrile at 40℃; for 6h; | 226 mg |