2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

Base Information

Chemical Name:2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine
CAS No.:137587-07-6
Molecular Formula:C₂₃H₁₉FIN
Molecular Weight:455.313
Hs Code.:

Synonyms:2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

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Chemical Property of 2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

Chemical Property:

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Technology Process of 2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

There total 10 articles about 2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 137587-07-6
2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / piperidine, HOAc / benzene / 22 h / Heating

2: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: 79 percent / 4-methylmorpholine N-oxide, 4A molecular sieves, tetrapropylammonium perruthenate (TPAP) / CH₂Cl₂ / 0.5 h / Ambient temperature

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With piperidine; lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; copper diacetate; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; ammonium acetate; iodine; tri-n-butyl-tin hydride; acetic acid; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; acetic acid; benzene;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-94-8
(Z)-2-Cyclopropanecarbonyl-3-(4-fluoro-phenyl)-acrylic acid ethyl ester

: 137587-07-6
2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LiN(TMS)2 / 1.) THF, -78 deg C, 1 h, 2.) THF, 1.5 h

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: 79 percent / 4-methylmorpholine N-oxide, 4A molecular sieves, tetrapropylammonium perruthenate (TPAP) / CH₂Cl₂ / 0.5 h / Ambient temperature

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With lithium aluminium tetrahydride; n-butyllithium; tetrapropylammonium perruthennate; copper diacetate; 2,2'-azobis(isobutyronitrile); 4 A molecular sieve; ammonium acetate; iodine; tri-n-butyl-tin hydride; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-97-1
2-Cyclopropyl-4-(4-fluorophenyl)-5-methyl-6-phenyl-3-pyridinecarboxaldehyde

: 137587-07-6
2-Cyclopropyl-3-(2-iodoethenyl)-4-(4-fluorophenyl)-5-methyl-6-phenylpyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

2: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With n-butyllithium; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00113a019