2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

Base Information

Chemical Name:2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate
CAS No.:1437281-44-1
Molecular Formula:C₂₅H₂₅N₃O₄S
Molecular Weight:463.557
Hs Code.:

Synonyms:2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

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Chemical Property of 2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

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Technology Process of 2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

There total 6 articles about 2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1437281-39-4
4-(6-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N,N-dimethylaniline

: 98-59-9
p-toluenesulfonyl chloride

: 1437281-44-1
2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: 4-(6-(2-((tert-butyldimethylsilyl)oxy)ethoxy)quinoxalin-2-yl)-N,N-dimethylaniline; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

p-toluenesulfonyl chloride; With dmap; In pyridine; at 20 ℃; for 6h;

Reference yield: 46.0%

: C₁₈H₁₉N₃O₂

: 98-59-9
p-toluenesulfonyl chloride

: 1437281-44-1
2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: With pyridine; dmap; at 20 ℃; for 6h;
DOI:10.1021/ml4000707

Reference yield:

: 1437281-38-3
6-(2-((tert-butyldimethylsilyl)oxy)ethoxy)-2-chloroquinoxaline

: 1437281-44-1
2-((2-(4-(dimethylamino)phenyl)quinoxalin-6-yl)oxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 3 h / Reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

3: pyridine; dmap / 6 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; ethanol; water; toluene;
DOI:10.1021/ml4000707