3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine

Base Information

• Chemical Name: 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine
• CAS No.: 1350816-85-1
• Molecular Formula: C₁₅H₁₃N₇S
• Molecular Weight: 323.381
• Mol file: 1350816-85-1.mol

Synonyms:3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine

Chemical Property of 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine

There total 2 articles about 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

3-(3,5-dimethylpyrazol-1-yl)imidazo[1,2-b][1,2,4,5]tetrazine (1231691-29-4) + thiophenol (108-98-5) → 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine (1350816-85-1)

Guidance literature:

With triethylamine; In acetonitrile; at 20 ℃;

DOI:10.1007/s11172-011-0155-2

Reference yield:

3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (30169-25-6) → 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine (1350816-85-1)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 0.17 h / 20 °C

2: acetic acid / 4 h / Reflux

3: triethylamine / acetonitrile / 20 °C

With acetic acid; triethylamine; In acetonitrile;

DOI:10.1007/s11172-011-0155-2

Reference yield: 60.0%

1-Heptylamine (111-68-2) + 3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine (1350816-85-1) → 3-(heptylamino)-6-(phenylthio)imidazo[1,2-b][1,2,4,5]tetrazine

Guidance literature:

In acetonitrile; for 2h;

DOI:10.1016/j.ejmech.2019.05.081

upstream raw materials:

3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine

3-(3,5-dimethylpyrazol-1-yl)imidazo[1,2-b][1,2,4,5]tetrazine

thiophenol