3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Base Information

• Chemical Name: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine
• CAS No.: 30169-25-6
• Molecular Formula: C12H14N8
• Molecular Weight: 270.297
• Hs Code.: 2933990090
• Mol file: 30169-25-6.mol

Synonyms:3,6-Bis(3,5-dimethylpyrazolyl)-1,2,4,5-tetraazine;Bis[3,5-(dimethylpyrazolyl)]-1,2,4,5-tetrazine;s-Tetrazine, 3,6-bis(3,5-dimethylpyrazol-1-yl)- (8CI);

Chemical Property of 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

Chemical Property:

• Melting Point: 216-218 °C
• Boiling Point: 533.695 °C at 760 mmHg
• PKA: -4.09±0.31(Predicted)
• Flash Point: 276.569 °C
• PSA: 61.42000
• Density: 1.448 g/cm³
• LogP: 2.08160
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine is a reagent used to prepare 3-arylamino-6-benzylamino-1,2,4,5-tetrazines with antimalarial activities.

Technology Process of 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine

There total 7 articles about 3,6-Bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,2,4,5-tetrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,4-dihydro-1,2,4,5-tetrazine (30169-21-2) → 3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (30169-25-6)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; nitric oxide; for 1h; Ambient temperature;

Reference yield: 98.0%

triaminoguanidine hydrochloride + acetylacetone (123-54-6,81235-32-7) → 3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (30169-25-6)

Guidance literature:

triaminoguanidine hydrochloride; acetylacetone; In water; at 30 - 70 ℃; for 5.33h;

With acetic acid; sodium nitrite; In water; at 20 ℃; for 6h; Cooling with ice;

Reference yield: 98.0%

3,6-bis(3,5-dimethylpyrazol-1-yl)-1,4-dihydro-1,2,4,5-tetrazine (30169-21-2) → 3,6-bis-(3,5-dimethyl-pyrazol-1-yl)-1,2,4,5-tetrazine (30169-25-6)

Guidance literature:

With Nitrogen dioxide; In 1-methyl-pyrrolidin-2-one; for 0.5h;

DOI:10.1039/c3cc46634e

upstream raw materials:

3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,4-dihydro-1,2,4,5-tetrazine

3,6-bis(3,5-dimethylpyrazol-1-yl)-1,4-dihydro-1,2,4,5-tetrazine

acetylacetone

triaminoguanidine hydrochloride

Downstream raw materials:

3,6-diamino-1,2,4,5-tetrazine

3,5-dimethyl-1H-pyrazole

3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,2,4,5-tetrazine

[6-(3,5-dimethyl-pyrazol-1-yl)-[1,2,4,5]tetrazin-3-yl]-p-tolyl-amine