methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

Base Information

Chemical Name:methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate
CAS No.:859154-69-1
Molecular Formula:C₁₈H₂₆ClN₃O₂S
Molecular Weight:383.942
Hs Code.:

Synonyms:methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

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Chemical Property of methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

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Technology Process of methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

There total 1 articles about methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 859154-57-7
tert-butyl (1-{[(4-chlorophenyl)amino]carbonothioyl}-piperidin-4-yl)carbamate

: 80-48-8
methyl p-toluene sulfonate

: 859154-69-1
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

Guidance literature:: tert-butyl (1-{[(4-chlorophenyl)amino]carbonothioyl}-piperidin-4-yl)carbamate; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.166667h;

methyl p-toluene sulfonate; In tetrahydrofuran; for 0.333333h;

Reference yield:

: 859154-69-1
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

: 868834-42-8
N₂-{1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-yl}pyridine-2,3-diamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / tetrahydrofuran; water / 7 h / Heating / reflux

2.1: hydrogenchloride; water / 1,4-dioxane / 66 h / 20 °C

2.2: 3 h / 50 °C

3.1: triethylamine / tetrahydrofuran / 18 h / 20 °C

3.2: 24 h / Heating / reflux

4.1: hydrogen / nickel / tetrahydrofuran; ethanol / 18 h / 1551.49 Torr

With hydrogenchloride; water; hydrogen; triethylamine; trifluoroacetic acid; nickel; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 859154-69-1
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

: N-{1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-yl}pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / tetrahydrofuran; water / 7 h / Heating / reflux

2.1: hydrogenchloride; water / 1,4-dioxane / 66 h / 20 °C

2.2: 3 h / 50 °C

3.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane / toluene / 18 h / Heating / reflux

With hydrogenchloride; water; trifluoroacetic acid; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; 1,4-dioxane; water; toluene;