1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

Base Information

Chemical Name:1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride
CAS No.:868833-82-3
Molecular Formula:C₁₄H₁₈ClN₅*ClH
Molecular Weight:328.244
Hs Code.:

Synonyms:1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

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Chemical Property of 1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

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Technology Process of 1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

There total 2 articles about 1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 859154-99-7
tert-butyl {1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidin-4-yl}carbamate

: 868833-82-3
1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

Guidance literature:: tert-butyl {1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidin-4-yl}carbamate; With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 66h;

With methanol; In 1,4-dioxane; at 50 ℃; for 3h;

Reference yield:

: 859154-69-1
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

: 868833-82-3
1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / tetrahydrofuran; water / 7 h / Heating / reflux

2.1: hydrogenchloride; water / 1,4-dioxane / 66 h / 20 °C

2.2: 3 h / 50 °C

With hydrogenchloride; water; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield: 30.0%

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 868833-82-3
1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride

: N-{1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-yl}-3-nitropyridin-2-amine

Guidance literature:: 2-Chloro-3-nitropyridine; 1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]-piperidin-4-amine hydrochloride; With triethylamine; In tetrahydrofuran; at 20 ℃; for 18h;

With N,N-dimethyl-formamide; In tetrahydrofuran; for 24h; Heating / reflux;