(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Base Information

Chemical Name:(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate
CAS No.:640721-04-6
Molecular Formula:C₁₉H₁₄BrNO₉
Molecular Weight:480.225
Hs Code.:

Synonyms:(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Suppliers and Price of (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

There total 5 articles about (6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 640721-02-4
6-bromo-4-hydroxymethyl-7-(methoxymethoxy)-2H-chromen-2-one

: 640721-04-6
(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja5055862

Reference yield:

: 223420-41-5
6-bnromo-7-hydroxy-4-(hydroxymethyl)-2H-chromen-2-one

: 640721-04-6
(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / diisopropylethylamine / CH₂Cl₂ / 0.67 h / 20 °C

2: 4-(dimethylamino)pyridine / acetonitrile / 1.5 h / 20 °C

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1021/ol0359362

Reference yield:

: 640721-03-5
[[6-bromo-7-(methoxymethoxy)coumarin-4-yl]methoxy]carbonyl chloride

: 640721-04-6
(6-bromo-7-(methoxymethoxy)-2-oxo-2H-chromen-4-yl)methyl(4-nitrophenyl) carbonate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 4-(dimethylamino)pyridine / acetonitrile / 0.67 h / 20 °C

2: 96 percent / trifluoroacetic acid / 0.5 h / 20 °C

3: KMOPS buffer / dimethylsulfoxide / pH 7.2 / Photolysis

4: 85 percent / diisopropylethylamine / CH₂Cl₂ / 0.67 h / 20 °C

5: 4-(dimethylamino)pyridine / acetonitrile / 1.5 h / 20 °C

With dmap; KMOPS buffer; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/ol0359362